The Southwest is Hispanic, from the start until today

Mayflower at 400: What we all get wrong about the Pilgrim Fathers

After all, the Mayflower didn't bring the first English settlers to these shores. Nor was the Plymouth Plantation the inaugural settlement. Jamestown in Virginia had been founded 13 years before. In the west, the Spanish had already settled Santa Fe, the capital of what's now New Mexico. And maybe it's worth stating the obvious from the outset - that the Pilgrim Fathers should not be confused with the Founding Fathers, the patriots who fought against the British in the revolutionary war, the visionaries who in 1776 launched this rambunctious experiment in democracy

The bold face is mine.

Santa Fe was the first generation Spanish colonialism. The Franciscans were the second.  The first real settlement in the USA was called Saint Faith, named after a Catholic.

According to Wiki:

The area of Santa Fe was originally occupied by indigenous Tanoan peoples, who lived in numerous Pueblo villages along the Rio Grande. One of the earliest known settlements in what today is downtown Santa Fe came sometime after 900 CE. A group of native Tewa built a cluster of homes that centered around the site of today's Plaza and spread for half a mile to the south and west; the village was called Oghá P'o'oge in Tewa[15] The Tanoans and other Pueblo peoples settled along the Santa Fe River for its water and transportation.

Don Juan de Oñate led the first European effort to colonize the region in 1598, establishing Santa Fe de Nuevo México as a province of New Spain.