Tuesday, May 5, 2020

So we can refine our method

Assume we want the proper antibody ratio.

We take the typical human assay of HC B cells and LC B cells, and compare that to the virus surface collection of HC and LC peptides. Since the vurs is novel, we expect a match, a concentration adjustment in which HC and LC most likely combine on that virus surface relative to nominal levels. We inject small potions of thetwo to push the bloodstream concentrations toward that bound.

There are more cheats.  Break you HC B cells into their groups. Try the best match first, monitor results. Then add in the second best. We really are aiming to get the diet back to normal. Move the antibodies back to neutral.

I am speculating that the out of balance system has too many HC B cells, tried and unused.  There should be a method of flushing the system with excess LC B-cells and see if any of the old stuff can find food.

The math is letting us treat a collection of LC B cells as a simple, but large collection of the total LC structure, within some bonds. But it seem natural for the B cell to make each of five sets. It have overlap, and I am sure we are dealing with five sets, each having five chain markers. The HC B cells are likely more flexible, allowing variable marking, and also more likely to clog the system.

The search space seems limited to 500 or so, the search to find the next chemokinetic step. But we have multiple LC B cells, that is path merging, we get one extra time step. We get some extra selectivity from the HC B cells, and our search times drops down to 20-50 sniffs per virus surface before we get a dissolution.

The extra time steps mean that once the HC has one or two pending, the LC can find a solution. That cuts the search in half right away. This antibody creation will hold if only one adjacent peptide matches with the HC.  It will take another sniff I think.  Each of these sniffs is a reversible reaction, redundancy added via energy. But the price paid is unnecessary consumption elsewhere. The adaptability is really in the ability of the HC B cell o utilize a wider variety of immunoglobulin against which to test.  It is the ability of N density o change, the system responds with a change of concentration to restore the total environment.

I have to check to see if I got that right. But if I recall these B cell HC cells could grab onto some immunoglobulin bundle with some variability.

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