Thursday, April 30, 2020

The virus enters a complex cell food supply in our body

All the cell reactions are like consumers in a complex ecology. The white cells, from the bone marrow, get tuned to a portion of virus. from the lymph system, and they gol hunting for food, in essence. The macro phages get first crack, they are from the thymus. and eat debris. But they emit cytokines which shuts down the debris flow from the tissues into the lymph, and this is severe swelling.

These cytokines are part of the cells basic ability to react to proteins outside the lipid layer, no cytoplasm lost. Cytoklin refers to the short chained proteins. In particular, the macorphases, opr the generic phagocyte, emits these, and some signal the lymph system.     Since the condition is considered a storm, it is congestion unmanaged, a requant.  So, there is a reaction between the phagocytes and the foreign proteins this is particular sensitive to these phagocytes, from the thymus.

Whew!!!

But why do we get out thymus cells get so sensitive to a particular type of molecule> It happen as we age, hmmm... Cause or effect?  The phagocytes love to eat corona, white cells never get a taste of them.  Either white never develops the taste, or phago just devours them? Our immunity to this viurs is short, white cells do not develop the taste.   So, allergies  are the inability to produce so many whites with varied tastes. We have a limited supply of differentiation in white cells. Don't waste them.

The majority of the young have white cell differentiation possibilities.  But if you are old, you white cells have been battling corona family virus for many years, your system is pooped.

Sounds like we have another coloring problem! Sandbox to the rescue.

Let us first note the docs job is more difficult than we imagined, because if the old have little white capacity, the the doc is relying on phagocyte, he is up against a hard bound. He needs a white cell anti-body booster.

Anyway, the white cell eats an anigen and multiplies!  The antigen feeds a white cell clone. And these clones hang around for years.  But corona clones have a wide distribution, and in that is the whole class of common colds.   There is no more room for another corona.

The lymph system in the middle of congestion will close, via cytokines.  It only wants completely digested material. This particular corona happens to be long lived and eventually tips the balance of the susceptible which shuts the lymph. If the doc forces the lymph open he risks heart damage because the lymph meets a big node up there. The doc needs something harmless which eats the temporary coron overload, direct, which shuts down the macrphage madness and opens the lymph.

Someone is getting a Nobel Banana on this.  Maybe a culture of specially trained anti-body, to be used only specific for this corona, or any other ARDS symptom.  Dangerous stunt, could lead to other infections.    Take the patients blood sample, get a white cell culture developed externally, using the proper corona sequence. Then inject it back. In fact, identify the susceptible before hand, create the culture, and keep a dose handy.

I cheat a bit since I know that genetic theory and information theory are well connected. But the white blood cells have to encode for the variety of the family. These cells will have limited genetic bandwidth, and there will exist a corona that is just outside its bound.

This is two channel constricted flow, antibody coding the corona family, a self sampling problem.  %he just enough new member of the virus will pass quickly through the population via aerosol. The more common corona reappear regularly and keep the anti-body channel busy, or packed.

The docs need to make a generic white cell culture based on this particular virus, one they can use anywhere.  Then in crisis, just unload the stuff and take the band width you need, keep flushing. The cytokine storm stopped.

Band limited under flow

So, as a child you develop an antibody for a benign food, but it hangs around. Your interaction with other antigens will be redistributed across the capacity,  antibody clones would be separated. Once your white cells get caught in a system supported by the environment   How do we reset the sequence?  On corona, we likely have limited capacity for that family, co-evolving with it.  If we find a vaccine against this virus, we likely over use the channel capacity and severe allergies show up elsewhere.  There is a reason for low immunity periods, there are a greater variety of this family coming and going. This is a channel encoding problem.

Since the immunity is short lived, the docs can use up the capacity for a short period, keeping the patient isolated. The the patient can re-introduce himself to the common cold.


No comments: